Safety data sheet chandlergilbert community college. Precautionary statements p261 avoid breathing dust. Acetylsalicylic acid asa makes the platelets in your blood less sticky. See actual entry in rtecs for complete information. In case of skin contact wash off with soap and plenty of water. Please note that some chemicals, such as hydrofluoric acid, require use of a special antidote such as calcium gluconate gel and. For this reason, it is industrially synthesized on a massive scale, producing up. However, we make no warranty of merchantability or any other warranty, express or implied, with respect to such information, and we assume no liability resulting from its use. Acetylsalicylic acid side effects, uses, dosage, overdose.
Basically i think that acetylsalicylic acid isnt very soluble in water because of its polarity. Chapter 7 safe chemical use cornell ehs cornell university. Not all of the mass of an aspirin tablet is acetylsalicylic acid, as there are starch binders added to hold the tablet together. Contact a licensed professional waste disposal service to dispose of this material. Sds of acetylsalicylic acid, safety data sheets, cas 50782. In folk medicine, willow bark teas were used as headache remedies and other tonics. The skills by the end of the experiment you should be able to. Aspirin also inhibits platelet aggregation and is used in the prevention of arterial and venous thrombosis. O acetylsalicylic acid 2acetoxybenzoic acid aspirin formula. Pdf salicylic acid sa is a critical plant hormone that is involved in many. There is no warranty of accuracy or completeness of any information contained herein. Material safety data sheet acetylsalicylic acid product observe all federal, state, and local environmental regulations. Pdf multiple targets of salicylic acid and its derivatives in plants. Links with this icon indicate that you are leaving the cdc website the centers for disease control and prevention cdc cannot attest to the accuracy of a nonfederal website.
Transfer of large quantities of flammables, acids, bases, or other hazardous materials. Aspirin material safety data sheet cas no 50782 sdsmsds. Organic chemistry ii january 30, 20 synthesis of aspirin acetylsalicylic acid using acid and base catalysis. The only other information i know,is that the acetylsalicylic acid reacts with hydroxide ion,from a standardized sodium hydroxide solution. Product and company identification acetylsalicylic acid.
The average tablet contains about 325 milligrams of the active ingredient acetylsalicylic acid combined with an inert binding material such as starch. How many 80mg aspirin tablets would a 160 pound person have to consume to ingest the estimated ld50 for acetylsalicylic acid. Ive tried researching on the net and so far i havent really got it, but i think im onto something. Methyl salicylate may be used by plants as a pheromone to warn other plants of pathogens such as tobacco mosaic virus. Safety data sheet according to 29cfr19101200 and ghs rev. The expected concentrations in the samples were chosen in a way to be close to middle range. The msds sheet for acetylsalicylic acid estimates its oral, single dose ld50 as 357 mg per kg in humans. Development of a new analytical method for determination of acetylsalicylic and salicylic acids 725 following experimental outline. One reagent lane fair lawn, nj 07410 for information in north america, call. Specific inflammatory conditions which aspirin is used to treat include kawasaki disease, pericarditis, and rheumatic fever. Development of a new analytical method for determination of. Buy acetylsalicylic acid 75mg150mg tablets at our pharmacy.
Disclaimer the sds samples above are collected from the internet by chemblink and displayed here for the tutorial purpose only. Aspirin, also known as acetylsalicylic acid asa, is a medication used to reduce pain, fever. Ac158180000, ac158180025, ac158185000, ac385760000 synonyms. Ac158180000, ac158180500, ac158185000, ac385760000 synonyms. Aspirin is the most widely used overthecounter drug in the world.
Acetylsalicylic acid solubilty organic chemistry science. Acetylsalicylic acid definition of acetylsalicylic acid by. Safety data sheet northwest missouri state university. Links with this icon indicate that you are leaving the cdc website the centers for disease control and prevention. Show this safety data sheet to the doctor in attendance. Dissolve or mix the material with a combustible solvent and burn in a chemical incinerator equipped with an afterburner and scrubber.
Sixty patients with 143 distal anastomoses of bypasses were randomized, 46 underwent repeat angiography after 4 months. Section 1 chemical product and company identification. Carbon monoxide, irritating and toxic fumes and gases, carbon dioxide. Synthesis of oil of wintergreen cornell center for.
So aso in the raman shft 550 cm1, there is a shift and this is a ccl bond, which indicates a different composition of the acetylsalicylic acid. Salicylic acid, whose name comes from salix, the willow family of plants, was derived from willow bark extracts. Salicigen, an extract of willow and poplar bark, has been used as a pain reliever. Dec 12, 2005 i know that acetylsalicylic acid isnt very soluble in water. Synthesis of oil of wintergreen pre lab discussion. Synthesis of acetylsalicylic acid dan jones, josh schmidt abstract acetylsalicylic acid, commonly known as aspirin, is considered to be the most successful pharmaceutical product in the world. Salicylic acid and its esters are used as food preservatives, in skincare products and other cosmetics, and in topical medicines. Also,one mol of oh reacts with one mole of acetylsalicylic acid. Coated, chewable, buffered, and extended release forms are available. If you forget a dose, take it as soon as you remember. Synthesis of aspirin acetylsalicylic acid using acid and base catalysis chm 2211c. Bioaccumulation accumulationno information available. Acetylsalicyclic acid definition of acetylsalicyclic acid. Aspirinalso known as acetylsalicylic acidis sold over the counter and comes in many forms, from the familiar white tablets to chewing gum and rectal suppositories.
Oacetylsalicylic acid is the prototypical analgesic used in the treatment of mild to moderate pain. The average tablet contains about 325 milligrams of the active ingredient acetylsalicylic acid combined with. Acetylsalicylic acid aspirin is a nonsteroidal antiinflammatory drug nsaid with properties that inhibit the proinflammatory status of the brain. Aspirin is the common name for the compound acetylsalicylic acid, widely used as a fever reducer and as a pain killer. In a business making drugs based on, for example, acetylsalicylic acid, a product that has been on the market for well over 100 years, the chances are there is often no new knowledge to be gained from psurs periodic safety update reports and single case handling, yet the dogged reporting and analysis still has to take place in order to. Material safety data sheets the syracuse city school district. Msds contains all of the information required by those regulations. Synthesis of acetylsalicylic acid aspirin using acid. Acetylsalicylic acid an overview sciencedirect topics. Acetylsalicylic acid is a white crystal or powder that is essentially odorless and has a slightly bitter taste. I know that acetylsalicylic acid isnt very soluble in water. Other references state that a 10 g dose 143 mgkg may be fatal in humans. Curiously, salicylic acid is also a metabolite of aspirin. If inhaled if breathed in, move person into fresh air.
Material safety data sheet acetylsalicylic acid if inhaled if breathed in, move person into fresh air. Excerpt from erg guide 154 substances toxic andor corrosive noncombustible. Immediately flush eyes with excess water for 15 minutes, lifting lower and upper eyelids occasionally. Acetylsalicylic acid is used for the treatment of fever as well as inflammation and pain caused by various conditions such as arthritis, menstrual pain, headache, migraines, muscle. Sigmaaldrich offers a number of acetylsalicylic acid products. E29 preparation of aspirin acetylsalicylic acid and thin. Search results for acetylsalicylic acid at sigmaaldrich. How many moles of acetylsalicylic acid molarmass 180. O acetylsalicylic acid is the prototypical analgesic used in the treatment of mild to moderate pain. If not breathing give artificial respiration consult a physician. Methyl salicylate c6h4 ho cooch3, also known as salicylic acid methyl ester, oil of wintergreen, is a natural product of many species of plants.
Jul 27, 2017 acetylsalicylic acid get uptodate information on acetylsalicylic acid side effects, uses, dosage, overdose, pregnancy, alcohol and more. Aspirin given shortly after a heart attack decreases the risk of death. Pharmacokinetics and pharmacodynamics of acetylsalicylic acid. Pharmacokinetics and pharmacodynamics of acetylsalicylic acid after intravenous and oral administration to healthy volunteers j nagelschmitz,1 m blunck,1 j kraetzschmar,1 m ludwig,1 g wensing,1 t hohlfeld2 1bayer healthcare ag, clinical pharmacology, wuppertal, germany. Aspirin or acetylsalicylic acid acetosal is a drug in the family of salicylates, often used as an analgesic against minor pains and aches, antipyretic against fever, and antiinflammatory. Aspirinalso known as acetylsalicylic acid is sold over the counter and comes in many forms, from the familiar white tablets to chewing gum and rectal suppositories. Abstract a new sensitive colorimetric method for determination of aspirin tablet in aqueous solution. Oacetylsalicylic acid 2acetoxybenzoic acid aspirin formula. Acetylsalicylic acid not listed as a carcinogen by acgih, iarc, ntp, or ca prop 65. Will likely be mobile in the environment due to its water solubility. In this lab, students will analyze aspirin acetylsalicylic acid tablets for the acetylsalicylic acid content, using a volumetric analysis technique called titration. Acetylsalicylic acid aspirin, a prodrug to salicylic acid, is made by an entirely different process. Aspirin, also known as acetylsalicylic acid asa, is a medication used to reduce pain, fever, or inflammation. E29 preparation of aspirin acetylsalicylic acid and thinlayer chromatography of analgesic drugs the task to prepare a pharmaceutical compound and test its purity.
The effect of lowdose acetylsalicylic acid 100 mgday upon bypass patencyrate and clinical course after aortocoronary bypass surgery was investigated in a randomized, placebocontrolled clinical trial. Acetylsalicylic acid is a white crystal or powder that is. Acetylsalicylic acid aspirin not listed not listed ec50 360 mgl 1 h ec50 900 mgl 1 h ec50. As an immediate precautionary measure, isolate spill or leak area in all directions for at least 50 meters 150 feet for liquids and at least 25 meters 75 feet for solids. Substitute less hazardous chemicals in your experiments whenever possible. Specifies the medication aspirin acetylsalicylic acid, aspirin, arthritis foundation safety coated aspirin, bayer aspirin, bayer childrens aspirin, ecotrin, and many others, a drug used for the treatment of arthritis, pain, inflammation, and fever. In this lab, we synthesized aspirin using both acid catalysis and base catalysis.312 70 989 185 1237 1111 1370 203 1446 610 1040 1279 62 1219 496 684 510 301 46 21 1331 1024 898 1463 402 862 792 375 1321 640